AZD-6280

• CAT Number: I003753
• CAS Number: 942436-93-3
• Molecular Formula: C20H22N4O3
• Molecular Weight: 366.41
• Purity: ≥95%
• Synonyms: 4-amino-8-(2,5-dimethoxyphenyl)-N-propylcinnoline-3-carboxamide
• InChI: InChI=1S/C20H22N4O3/c1-4-10-22-20(25)19-17(21)14-7-5-6-13(18(14)23-24-19)15-11-12(26-2)8-9-16(15)27-3/h5-9,11H,4,10H2,1-3H3,(H2,21,23)(H,22,25)
• InChIKey: NVWCZRPXYVDQEE-UHFFFAOYSA-N
• SMILES: CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC(=C3)OC)OC

AZD-6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized anxiety disorder.

Reference

[1]. Te Beek ET, et al. The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels. Clin Pharmacol Drug Dev. 2015 Mar;4(2):149-54. doi: 10.1002/cpdd.134. Epub 2014 Aug 28.
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