AZD-9291 mesylate

• CAT Number: I001623
• CAS Number: 1421373-66-1
• Molecular Formula: C₂₉H₃₇N₇O₅S
• Molecular Weight: 595.71
• Purity: ≥95%
• Synonyms: (Z)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylimidic acid compound with methanesulfonic acid (1:1)
• Target: Protein Tyrosine Kinase/RTK
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• Related CAS: 1421373-65-0(free base)
• IC50: 12.92 nM(Exon 19 deletion EGFR); 11.44 nM(L858R/T790M EGFR)
• IUPAC Name: N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
• InChI: InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)
• InChIKey: FUKSNUHSJBTCFJ-UHFFFAOYSA-N
• SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O

AZD-9291 mesylate (CAT: I001623) is a potent and selective inhibitor of mutated forms of the epidermal growth factor receptor (EGFR). Specifically, it targets EGFR mutations such as T790M, which is associated with resistance to traditional EGFR inhibitors. AZD-9291 mesylate acts by irreversibly binding to the mutant EGFR, inhibiting its tyrosine kinase activity and preventing downstream signaling pathways involved in tumor growth and survival. This targeted therapy has shown promising results in the treatment of non-small cell lung cancer (NSCLC) harboring EGFR mutations, offering a potential treatment option for patients with resistance to standard EGFR inhibitors.