AZD-CO-Ph-PEG4-Ph-CO-AZD

• CAT Number: I045236
• CAS Number: 2569143-72-0
• Molecular Formula: C26H28N2O8
• Molecular Weight: 496.51
• Purity: ≥95%
• Synonyms: 1-[4-[2-[2-[2-[4-(2-oxoazetidine-1-carbonyl)phenoxy]ethoxy]ethoxy]ethoxy]benzoyl]azetidin-2-one
• InChI: InChI=1S/C26H28N2O8/c29-23-9-11-27(23)25(31)19-1-5-21(6-2-19)35-17-15-33-13-14-34-16-18-36-22-7-3-20(4-8-22)26(32)28-12-10-24(28)30/h1-8H,9-18H2
• InChIKey: UTXXKKZMYZBDCT-UHFFFAOYSA-N
• SMILES: C1CN(C1=O)C(=O)C2=CC=C(C=C2)OCCOCCOCCOC3=CC=C(C=C3)C(=O)N4CCC4=O

AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis[1].

Reference

[1]. Alex R Nanna, et al.Generation and validation of structurally defined antibody-siRNA conjugates. Nucleic Acids Res. 2020 Jun 4;48(10):5281-5293.
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