AZD1480

• CAT Number: I005557
• CAS Number: 935666-88-9
• Molecular Formula: C₁₄H₁₄ClFN₈
• Molecular Weight: 348.77
• Purity: 98%
• Synonyms: AZD1480;AZD 1480
• Target: JAK
• Solubility: DMSO ≥68mg/mL Water <1.2mg/mL Ethanol ≥4.7mg/mL
• Appearance: White Powder
• Storage: 3 years -20 ℃
• IC50: 0.26 nM
• IUPAC Name: 5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
• InChI: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
• InChIKey: PDOQBOJDRPLBQU-QMMMGPOBSA-N
• SMILES: CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F

AZD1480 is a potent and selective inhibitor of Janus kinase 2 (JAK2), playing a critical role in research focused on cancer and inflammatory diseases. By inhibiting JAK2, AZD1480 disrupts the JAK-STAT signaling pathway, which is implicated in the progression of various cancers and autoimmune disorders. This compound is essential for preclinical studies aiming to understand the therapeutic potential of JAK2 inhibition in oncology and immunology. AZD1480 is a valuable tool for researchers investigating new treatments for conditions such as myeloproliferative disorders, leukemia, and other JAK2-dependent diseases.