For research use only. Not for therapeutic Use.
AZD3514(CAT: I000960) is a potent and selective small-molecule inhibitor of the androgen receptor (AR) signaling pathway, widely used in prostate cancer research. It works by reducing androgen receptor levels and inhibiting AR signaling, thereby disrupting the growth of AR-dependent tumor cells. AZD3514 is particularly valuable for investigating mechanisms of castration-resistant prostate cancer (CRPC) and exploring new therapeutic strategies. With high specificity and efficacy, it is suitable for in vitro and in vivo studies, providing a reliable tool for advancing research into androgen receptor biology and the development of targeted treatments for AR-driven malignancies.
| Catalog Number | I000960 |
| CAS Number | 1240299-33-5 |
| Synonyms | AZD-3514;AZD 3514 |
| Molecular Formula | C25H32F3N7O2 |
| Purity | ≥95% |
| Target | Androgen Receptor |
| Solubility | DMSO 100 mg/ml |
| Storage | -20°C |
| IC50 | 2.2 uM (Ki) |
| IUPAC Name | 1-[4-[2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-1-yl]ethanone |
| InChI | InChI=1S/C25H32F3N7O2/c1-18(36)33-14-12-32(13-15-33)16-17-37-21-4-2-19(3-5-21)20-8-10-34(11-9-20)23-7-6-22-29-30-24(25(26,27)28)35(22)31-23/h2-5,20H,6-17H2,1H3 |
| InChIKey | JMEYDSHPKCSIJC-UHFFFAOYSA-N |
| SMILES | CC(N1CCN(CCOC2=CC=C(C3CCN(C4=NN5C(CC4)=NN=C5C(F)(F)F)CC3)C=C2)CC1)=O |
