For research use only. Not for therapeutic Use.
AZD4320（Cat No.:I020064） is a dual BET (Bromodomain and Extra-Terminal domain) protein inhibitor, designed to disrupt the interaction between BET proteins and acetylated histones. This action modulates gene expression, influencing pathways involved in cancer progression and inflammation. AZD4320’s targeted mechanism aims to provide therapeutic benefits in oncology, particularly in treating hematological malignancies and potentially solid tumors. By inhibiting BET proteins, AZD4320 may effectively decrease proliferation and induce apoptosis in cancer cells. It is under investigation for its potential to improve outcomes in diseases driven by abnormal gene expression regulated by BET proteins.
| Catalog Number | I020064 |
| CAS Number | 1357576-48-7 |
| Molecular Formula | C₄₅H₄₈ClF₃N₄O₇S₃ |
| Purity | ≥95% |
| Target | Bcl-2 Family |
| IUPAC Name | 4-[4-[(R)-[2-(4-chlorophenyl)phenyl]-hydroxymethyl]piperidin-1-yl]-N-[4-[[(2R)-4-[2-hydroxyethyl(methyl)amino]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide |
| InChI | InChI=1S/C45H48ClF3N4O7S3/c1-52(27-28-54)24-23-35(30-61-37-7-3-2-4-8-37)50-41-20-19-38(29-42(41)62(57,58)45(47,48)49)63(59,60)51-44(56)33-13-17-36(18-14-33)53-25-21-32(22-26-53)43(55)40-10-6-5-9-39(40)31-11-15-34(46)16-12-31/h2-20,29,32,35,43,50,54-55H,21-28,30H2,1H3,(H,51,56)/t35-,43-/m1/s1 |
| InChIKey | UNEJSHNDABUZNY-UJNHCCGESA-N |
| SMILES | CN(CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCC(CC4)C(C5=CC=CC=C5C6=CC=C(C=C6)Cl)O)S(=O)(=O)C(F)(F)F)CCO |
