For research use only. Not for therapeutic Use.
AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1].
Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1].
| Catalog Number | I003646 |
| CAS Number | 1054629-49-0 |
| Synonyms | 2-[2-fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol |
| Molecular Formula | C14H11FN2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H11FN2O2/c1-16-13-5-3-10(14(15)17-13)12-7-8-6-9(18)2-4-11(8)19-12/h2-7,18H,1H3,(H,16,17) |
| InChIKey | MYNQXTDIPMCJCR-UHFFFAOYSA-N |
| SMILES | CNC1=NC(=C(C=C1)C2=CC3=C(O2)C=CC(=C3)O)F |
| Reference | [1]. Juréus A, Swahn BM, Sandell J, et al. Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand. J Neurochem. 2010;114(3):784-794. |
