AZD4694 Precursor

• CAT Number: I044390
• CAS Number: 1211333-20-8
• Molecular Formula: C22H25N3O7
• Molecular Weight: 443.45
• Purity: ≥95%
• Synonyms: tert-butyl N-[5-[5-(ethoxymethoxy)-1-benzofuran-2-yl]-6-nitropyridin-2-yl]-N-methylcarbamate
• InChI: InChI=1S/C22H25N3O7/c1-6-29-13-30-15-7-9-17-14(11-15)12-18(31-17)16-8-10-19(23-20(16)25(27)28)24(5)21(26)32-22(2,3)4/h7-12H,6,13H2,1-5H3
• InChIKey: YDLUIXGYKWYMMC-UHFFFAOYSA-N
• SMILES: CCOCOC1=CC2=C(C=C1)OC(=C2)C3=C(N=C(C=C3)N(C)C(=O)OC(C)(C)C)[N+](=O)[O-]

AZD4694 Precursor (AZ13040214) is the precursor of [18F] AZD4694 for the synthesis of [18F] AZD4694, an amyloid-β imaging ligand with high affinity for amyloid-β plaques[1].
AZD4694 Precursor is an amyloid-β imaging ligand with high affinity for amyloid-β plaques. AZD4694 Precursor is a high affinity (Kd= 2.3 nM) radioligand for imaging amyloid-β plaques that displays lower white matter binding compared to other fluorinated amyloid-PET tracers, enabling easier visual reads[1].

Reference

[1]. Therriault J, et al. Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging. J Nucl Med. 2021;62(2):247-252.
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