For research use only. Not for therapeutic Use.
AZD4747(CAT: I040992) is a potent and selective FGFR (Fibroblast Growth Factor Receptor) inhibitor, primarily targeting FGFR1, FGFR2, and FGFR3. It is designed for cancer research, particularly in tumors driven by FGFR gene alterations, such as bladder cancer, breast cancer, and gastric cancer. AZD4747 effectively suppresses FGFR signaling, leading to the inhibition of tumor growth and survival. It serves as a valuable tool for studying oncogenic FGFR pathways, resistance mechanisms, and targeted therapy strategies. Suitable for biochemical, cellular, and preclinical studies. For research use only; not for human or clinical applications.
| Catalog Number | I040992 |
| CAS Number | 2489226-14-2 |
| Synonyms | 1-[(4aR)-8-(2-chloro-6-hydroxyphenyl)-7-fluoro-9-prop-1-ynyl-1,2,4,4a,5,11-hexahydropyrazino[2,1-c][1,4]benzoxazepin-3-yl]prop-2-en-1-one |
| Molecular Formula | C24H22ClFN2O3 |
| Purity | ≥95% |
| IUPAC Name | 1-[(4aR)-8-(2-chloro-6-hydroxyphenyl)-7-fluoro-9-prop-1-ynyl-1,2,4,4a,5,11-hexahydropyrazino[2,1-c][1,4]benzoxazepin-3-yl]prop-2-en-1-one |
| InChI | InChI=1S/C24H22ClFN2O3/c1-3-6-15-11-16-12-27-9-10-28(20(30)4-2)13-17(27)14-31-24(16)23(26)21(15)22-18(25)7-5-8-19(22)29/h4-5,7-8,11,17,29H,2,9-10,12-14H2,1H3/t17-/m1/s1 |
| InChIKey | CNQOLVBNICGIJB-QGZVFWFLSA-N |
| SMILES | CC#CC1=C(C(=C2C(=C1)CN3CCN(CC3CO2)C(=O)C=C)F)C4=C(C=CC=C4Cl)O |
