AZD5363 dihydrochloride

• CAT Number: I047571
• CAS Number: 2108875-84-7
• Molecular Formula: C21H25ClN6O2.2HCl
• Molecular Weight: 501.84
• Purity: ≥95%
• IUPAC Name: 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide;dihydrochloride
• InChI: InChI=1S/C21H25ClN6O2.2ClH/c22-15-3-1-14(2-4-15)17(6-12-29)27-20(30)21(23)7-10-28(11-8-21)19-16-5-9-24-18(16)25-13-26-19;;/h1-5,9,13,17,29H,6-8,10-12,23H2,(H,27,30)(H,24,25,26);2*1H/t17-;;/m0../s1
• SMILES: C1CN(CCC1(C(=O)N[C@@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4.Cl.Cl

Orally bioavailable, selective and potent protein kinase B (Akt) inhibitor in low nM potency; AZD5363 dihydrochloride is directly water-soluble.
KEYWORDS: AZD5363 dihydrochloride | supplier | Akt inhibitor | Capivasertib | AZD-5363 | AZD 5363 | CAS [1143532-39-1] | Axon Medchem | Axon 1859 | Phosphatidylinositol | Akt | Inhibitor | Enzymes

Reference

BR Davies et al. Preclinical Pharmacology of AZD5363, an Orally Bioavailable Inhibitor of AKT: Pharmacodynamics, Antitumor Activity and Correlation of Monotherapy Activity with Genetic Background. Mol. Cancer Ther. 2012, 11(4), 873-887.