For research use only. Not for therapeutic Use.
AZD5582 (CAT: I001035) is a potent and selective inhibitor of apoptosis proteins (IAPs). It acts by binding to and antagonizing the activity of several IAPs, such as XIAP, cIAP1, and cIAP2. By inhibiting IAPs, AZD5582 promotes apoptosis (programmed cell death) and sensitizes cancer cells to the effects of chemotherapy and radiation therapy. It has demonstrated anti-tumor activity in preclinical studies, making it a promising candidate for the treatment of various cancers. AZD5582 represents a novel approach to targeting IAPs and has the potential to enhance the efficacy of current cancer treatments.
| Catalog Number | I001035 |
| CAS Number | 1258392-53-8 |
| Molecular Formula | C58H78N8O8 |
| Purity | ≥95% |
| Target | IAP; Apoptosis |
| Solubility | DMSO: ≥ 66.25 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 15/21/15 nM (cIAP1/cIAP2/XIAP) [1] |
| Reference | </br>1:AZD5582, an IAP antagonist that leads to apoptosis in head and neck squamous cell carcinoma cell lines and is eligible for combination with irradiation. Kadletz L, Enzenhofer E, Kotowski U, Altorjai G, Heiduschka G.Acta Otolaryngol. 2017 Mar;137(3):320-325. doi: 10.1080/00016489.2016.1242776. Epub 2016 Oct 14. PMID: 27739348 </br>2:A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer. Moon JH, Shin JS, Hong SW, Jung SA, Hwang IY, Kim JH, Choi EK, Ha SH, Kim JS, Kim KM, Hong DW, Kim D, Kim YS, Kim JE, Kim KP, Hong YS, Choi EK, Lee JS, Hattersley M, Jin DH, Kim TW.Oncotarget. 2015 Sep 29;6(29):26895-908. doi: 10.18632/oncotarget.4822. PMID: 26314849 Free PMC Article</br>3:Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). Hennessy EJ, Adam A, Aquila BM, Castriotta LM, Cook D, Hattersley M, Hird AW, Huntington C, Kamhi VM, Laing NM, Li D, MacIntyre T, Omer CA, Oza V, Patterson T, Repik G, Rooney MT, Saeh JC, Sha L, Vasbinder MM, Wang H, Whitston D.J Med Chem. 2013 Dec 27;56(24):9897-919. doi: 10.1021/jm401075x. Epub 2013 Dec 13. PMID: 24320998 |
