AZD5991

• CAT Number: I019687
• CAS Number: 2143010-83-5
• Molecular Formula: C35H34ClN5O3S2
• Molecular Weight: 672.26
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC1=C2C(=NN1C)CSCC3=NN(C(=C3)CSC4=CC5=CC=CC=C5C(=C4)OCCCC6=C(N(C7=C6C=CC(=C27)Cl)C)C(=O)O)C

AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.

Reference

[1] Tron AE, et al. Nat Commun. 2018, 9(1):5341.
[2] Garner TP, et al. Curr Opin Chem Biol. 2017, 39:133-142.
[3] Adriana E. Tron, et al. AACR Cancer Res. 2018, 78(13 Suppl):Abstract nr 302.