For research use only. Not for therapeutic Use.
AZD7545 (CAT: I002856) is a novel small-molecule inhibitor that exhibits selectivity towards PDHK2 (PDH kinase 2). PDHK2 is an enzyme involved in the regulation of pyruvate dehydrogenase (PDH), a key enzyme in the metabolism of glucose. By inhibiting PDHK2, AZD7545 interferes with the phosphorylation of PDH, leading to increased PDH activity and subsequent promotion of glucose oxidation. This modulation of glucose metabolism has potential implications in various physiological and pathological conditions, including metabolic disorders and cancer.
| Catalog Number | I002856 |
| CAS Number | 252017-04-2 |
| Synonyms | 4-[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]phenyl]sulfonyl-N,N-dimethylbenzamide |
| Molecular Formula | C19H18ClF3N2O5S |
| Purity | ≥95% |
| Target | PDHK |
| Solubility | DMSO: ≥ 46 mg/mL |
| Storage | Store at -20C |
| IC50 | 36.8 nM (PDHK1); 6.4 nM (PDHK2) [1] |
| IUPAC Name | 4-[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]phenyl]sulfonyl-N,N-dimethylbenzamide |
| InChI | InChI=1S/C19H18ClF3N2O5S/c1-18(28,19(21,22)23)17(27)24-15-9-8-13(10-14(15)20)31(29,30)12-6-4-11(5-7-12)16(26)25(2)3/h4-10,28H,1-3H3,(H,24,27)/t18-/m1/s1 |
| InChIKey | DTDZLJHKVNTQGZ-GOSISDBHSA-N |
| SMILES | CC(C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O |
| Reference | </br>1:Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. Kato M, Li J, Chuang JL, Chuang DT.Structure. 2007 Aug;15(8):992-1004. Epub 2007 Aug 2. PMID: 17683942 Free PMC Article</br>2:Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2. Tuganova A, Klyuyeva A, Popov KM.Biochemistry. 2007 Jul 24;46(29):8592-602. Epub 2007 Jun 30. PMID: 17602666 Free PMC Article</br>3:AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. Morrell JA, Orme J, Butlin RJ, Roche TE, Mayers RM, Kilgour E.Biochem Soc Trans. 2003 Dec;31(Pt 6):1168-70. PMID: 14641019 </br>4:AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats. Mayers RM, Butlin RJ, Kilgour E, Leighton B, Martin D, Myatt J, Orme JP, Holloway BR.Biochem Soc Trans. 2003 Dec;31(Pt 6):1165-7. Review. PMID: 14641018 |
