For research use only. Not for therapeutic Use.
Potent and selective inhibitor of checkpoint kinase (CHK; IC50 values 5 nM for Chk1/Chk2).
KEYWORDS: AZD7762 hydrochloride | supplier | CHK inhibitor | AZD 7762 | AZD-7762 | CAS [860352-01-8] – [1246094-78-9] | DNA-RNA | checkpoint kinase | CHK1 | CHK2 | stem cell | hematopoetic | HCS
| Catalog Number | I011129 |
| CAS Number | 1246094-78-9 |
| Molecular Formula | C17H19FN4O2S.HCl |
| Purity | ≥95% |
| IUPAC Name | 3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride |
| InChI | InChI=1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1 |
| SMILES | C1C[C@@H](CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N.Cl |
| Reference | JW Janetka et al, Inhibitors of Checkpoint Kinases: From discovery to the clinic. Curr. Opin. Drug Discov. & Devel. 2007, 10(4), 473-486.
S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.
SD Zabludoff et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 2008, 7(9), 2955-2966.
L Carrassa et al. Role of Chk1 in the differentiation program of hematopoietic stem cells. Cell. Mol. Life Sci. 2010, 67, 1713–1722. |
