For research use only. Not for therapeutic Use.
AZD9496 Deacrylic Acid Phenol(CAT: I040869) is a selective estrogen receptor degrader (SERD) used in Cancer Disease Research, specifically in the treatment of hormone receptor-positive breast cancer. This compound binds to the estrogen receptor (ER) and induces conformational changes that promote its degradation through the ubiquitin-proteasome pathway, thereby reducing the levels of the estrogen receptor and inhibiting estrogen-driven tumor growth. AZD9496’s action interferes with the ER signaling pathway, which is crucial in the progression of breast cancer, especially in cases resistant to traditional endocrine therapies. By targeting and degrading ER, AZD9496 offers a potential therapeutic approach for combating resistant breast cancer.
| CAS Number | 2173404-70-9 |
| Synonyms | 3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenol |
| Molecular Formula | C22H23F3N2O |
| Purity | ≥95% |
| IUPAC Name | 3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenol |
| InChI | InChI=1S/C22H23F3N2O/c1-12-8-15-14-6-4-5-7-18(14)26-20(15)21(27(12)11-22(2,3)25)19-16(23)9-13(28)10-17(19)24/h4-7,9-10,12,21,26,28H,8,11H2,1-3H3/t12-,21-/m1/s1 |
| InChIKey | UQFNAXIUJPIITK-XUSGNXJCSA-N |
| SMILES | C[C@@H]1CC2=C([C@H](N1CC(C)(C)F)C3=C(C=C(C=C3F)O)F)NC4=CC=CC=C24 |
