Azelastine-d3

• CAT Number: R043849
• CAS Number: 758637-88-6
• Molecular Formula: C₂₂H₂₁D₃ClN₃O
• Molecular Weight: 384.92
• Purity: ≥95%
• Synonyms: 4-[(4-Chlorophenyl)methyl]-2-[hexahydro-1-(methyl-13C,d3)-1H-azepin-4-yl]-1(2H)-phthalazinone-d3
• Storage: -20°C
• IUPAC Name: 4-[(4-chlorophenyl)methyl]-2-[1-(trideuteriomethyl)azepan-4-yl]phthalazin-1-one
• InChI: InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3/i1D3
• InChIKey: MBUVEWMHONZEQD-FIBGUPNXSA-N
• SMILES: [2H]C([2H])([2H])N1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl

Azelastine-d3 is a deuterated form of azelastine, with three deuterium atoms incorporated into its molecular structure. This high-purity isotopically labeled compound is essential for research in pharmacology, particularly in the study of antihistamines, drug metabolism, and pharmacokinetics. Azelastine-d3 is particularly valuable for investigating the metabolic pathways, bioavailability, and therapeutic efficacy of azelastine, an antihistamine used to treat allergic rhinitis and conjunctivitis. The deuterium labeling allows for precise tracking and quantification in biological systems using mass spectrometry, enhancing the accuracy of studies on drug absorption, distribution, metabolism, and excretion. This compound is a critical tool for researchers focused on optimizing antihistamine therapies, understanding the pharmacodynamics of azelastine, and developing new therapeutic strategies for allergy treatment, providing reliable and consistent results in various experimental settings.