For research use only. Not for therapeutic Use.
Azelastine Hydrochloride(Cat No.:A000915)is a potent, long-acting antihistamine used primarily for treating allergic rhinitis and conjunctivitis. As a selective H1-receptor antagonist, it works by blocking histamine, the chemical responsible for allergic symptoms such as sneezing, runny nose, and itchy eyes. Azelastine Hydrochloride also exhibits anti-inflammatory properties, making it effective in reducing nasal congestion and inflammation. Its rapid onset of action and minimal sedative effects make it a popular choice for managing seasonal and perennial allergies. It is available in nasal spray and ophthalmic solutions for targeted relief.
Catalog Number | A000915 |
CAS Number | 79307-93-0 |
Synonyms | Astelin; AZELASTINE HCl; Optivar; 79307-93-0; Allergodil |
Molecular Formula | C22H25Cl2N3O |
Purity | ≥95% |
Target | Neuronal Signaling |
Solubility | Soluble in DMSO > 10 mM |
Storage | -20°C |
IUPAC Name | 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one;hydrochloride |
InChI | InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H |
InChIKey | YEJAJYAHJQIWNU-UHFFFAOYSA-N |
SMILES | CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl |
Reference | 1: Karpishchenko SA, Kolesnikova OM. [The effectiveness of the combination of 2: Scadding G, Price D, El-Shanawany T, Ahmed S, Ray J, Sargur R, Kumar N. <br> 4: Merey HA, El-Mosallamy SS, Hassan NY, El-Zeany BA. Simultaneous determination <br> 6: Ridolo E, Montagni M, Melli V, Bonzano L, Incorvaia C, Canonica GW. A role for 7: Bousquet J, Bachert C, Bernstein J, Canonica GW, Carr W, Dahl R, Demoly P, 8: Harrow B, Hofmeister J, Gever LN, Karafilidis J, Lacey MJ, Scheibling CM, 9: Fu LL, Liu J, Chen Y, Wang FT, Wen X, Liu HQ, Wang MY, Ouyang L, Huang J, Bao 10: Berger WE, Shah S, Lieberman P, Hadley J, Price D, Munzel U, Bhatia S. |