Azelastine

• CAT Number: I004190
• CAS Number: 58581-89-8
• Molecular Formula: C22H24ClN3O
• Molecular Weight: 381.90
• Purity: ≥95%
• Target: Histamine Receptor
• Solubility: 10mM in DMSO
• Storage: 3 years -20℃ powder
• IUPAC Name: 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
• InChI: InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3
• InChIKey: MBUVEWMHONZEQD-UHFFFAOYSA-N
• SMILES: CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl

Azelastine（Cat No.:I004190）is a second-generation antihistamine commonly used to treat allergic rhinitis and conjunctivitis. It works by blocking histamine H1 receptors, reducing allergy symptoms such as sneezing, runny nose, itchy eyes, and nasal congestion. Azelastine is available as a nasal spray and eye drops, providing localized relief with minimal sedative effects compared to first-generation antihistamines. It also exhibits anti-inflammatory properties by inhibiting the release of other mediators involved in allergic reactions. Its fast-acting and long-lasting effects make it a preferred choice for managing seasonal and perennial allergies.

Reference

[1]. Kempuraj, D., et al., Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells. Ann Allergy Asthma Immunol, 2002. 88(5): p. 501-6.

[2]. Canonica, G.W., et al., Topical azelastine in perennial allergic conjunctivitis. Curr Med Res Opin, 2003. 19(4): p. 321-9.

[3]. Lieberman, P., M.A. Kaliner, and W.J. Wheeler, Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. Curr Med Res Opin, 2005. 21(4): p. 611-8.