Azelnidipine

• CAT Number: A000447
• CAS Number: 123524-52-7
• Molecular Formula: C33H34N4O6
• Molecular Weight: 582.65
• Purity: ≥95%
• Synonyms: 123524-52-7; Calblock; 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; CS-905; Azelnidipine [INN]
• Target: Neuronal Signaling
• Solubility: >27.15mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• InChI: 1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
• InChIKey: ZKFQEACEUNWPMT-UHFFFAOYSA-N
• SMILES: CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC(C)C

Azelnidipine is a long-acting dihydropyridine calcium channel blocker used in cardiovascular research for its antihypertensive properties. By selectively inhibiting L-type calcium channels, it reduces calcium influx into vascular smooth muscle cells, leading to vasodilation and lowered blood pressure. Azelnidipine’s unique property of minimal reflex tachycardia and antioxidant effects makes it ideal for exploring vascular protection and oxidative stress. Its prolonged action and high lipophilicity contribute to sustained blood pressure control, making it a valuable compound in hypertension and cardiovascular disease studies.