For research use only. Not for therapeutic Use.
Azidamfenicol（Cat No.:M058985）is a synthetic derivative of chloramphenicol, known for its broad-spectrum antibacterial properties, particularly against both Gram-positive and Gram-negative bacteria. It functions by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, which prevents peptide bond formation and halts bacterial growth. Azidamfenicol has shown potential in treating infections similar to those targeted by chloramphenicol, though its use is limited due to the risk of adverse effects, including hematological toxicity. Its chemical modifications aim to enhance efficacy while mitigating some of the side effects associated with chloramphenicol.
| Catalog Number | M058985 |
| CAS Number | 13838-08-9 |
| Molecular Formula | C11H13N5O5 |
| Purity | 99% |
| Appearance | white solid |
| Storage | Store at -20°C |
| Analysis method | HPLC |
| IUPAC Name | 2-azido-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide |
| InChI | InChI=1S/C11H13N5O5/c12-15-13-5-10(18)14-9(6-17)11(19)7-1-3-8(4-2-7)16(20)21/h1-4,9,11,17,19H,5-6H2,(H,14,18)/t9-,11-/m1/s1 |
| InChIKey | SGRUZFCHLOFYHZ-MWLCHTKSSA-N |
| SMILES | C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)CN=[N+]=[N-])O)[N+](=O)[O-] |
| Reference | 1-p-Nitrophenyl-2-azidoacetylaminopropane derivatives. Meiser W. & Domagk G. 1959 US Patent 2,882,275. |
