Azide-A-DSBSO crosslinker

• CAT Number: I040161
• CAS Number: 1704097-02-8
• Molecular Formula: C24H33N5O12S2
• Molecular Weight: 647.68
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-[[2-(3-azidopropyl)-5-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]sulfinylmethyl]-2-methyl-1,3-dioxan-5-yl]methylsulfinyl]propanoate
• InChI: InChI=1S/C24H33N5O12S2/c1-23(9-2-10-26-27-25)38-13-24(14-39-23,15-42(36)11-7-21(34)40-28-17(30)3-4-18(28)31)16-43(37)12-8-22(35)41-29-19(32)5-6-20(29)33/h2-16H2,1H3
• InChIKey: AKLJWXIVLPURNY-UHFFFAOYSA-N
• SMILES: CC1(OCC(CO1)(CS(=O)CCC(=O)ON2C(=O)CCC2=O)CS(=O)CCC(=O)ON3C(=O)CCC3=O)CCCN=[N+]=[N-]

Azide-A-DSBSO crosslinker (Cat No.: I040161) is a chemical compound used in bioconjugation and protein-protein interaction studies. The crosslinker contains an azide group that facilitates click chemistry reactions, allowing for the selective attachment of other molecules or biomolecules. The DSBSO (disulfide-bis-sulfonate) group can undergo reversible disulfide bond formation, enabling controlled crosslinking in cellular or biochemical contexts. This crosslinker is useful for studying protein dynamics, interactions, and complex formation, and has potential applications in drug discovery, proteomics, and targeted therapeutics.

Reference

[1]. Matzinger M, et al. Fast and Highly Efficient Affinity Enrichment of Azide-A-DSBSO Cross-Linked Peptides. J Proteome Res. 2020 May 1;19(5):2071-2079.
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