Azide-PEG2-MS

• CAT Number: I016003
• CAS Number: 176520-23-3
• Molecular Formula: C5H11N3O4S
• Molecular Weight: 209.22
• Purity: ≥95%
• Synonyms: 2-(2-azidoethoxy)ethyl methanesulfonate
• InChI: InChI=1S/C5H11N3O4S/c1-13(9,10)12-5-4-11-3-2-7-8-6/h2-5H2,1H3
• InChIKey: WDDYPDGUFZTNJJ-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)OCCOCCN=[N+]=[N-]

Azide-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG2-MS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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