For research use only. Not for therapeutic Use.
Azide-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG2-MS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016003 |
| CAS Number | 176520-23-3 |
| Synonyms | 2-(2-azidoethoxy)ethyl methanesulfonate |
| Molecular Formula | C5H11N3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C5H11N3O4S/c1-13(9,10)12-5-4-11-3-2-7-8-6/h2-5H2,1H3 |
| InChIKey | WDDYPDGUFZTNJJ-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)OCCOCCN=[N+]=[N-] |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
