For research use only. Not for therapeutic Use.
FTY720 is a derivative of ISP-<wbr></wbr>1 (myriocin), a fungal metabolite of the Chinese herb <em>Iscaria sinclarii</em> as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-<wbr></wbr>1-<wbr></wbr>phosphate (S1P) receptors (S1P<sub>1</sub>, S1P<sub>3</sub>, S1P<sub>4</sub>, and S1P<sub>5</sub>). Down-<wbr></wbr>regulation of S1P<sub>1</sub> receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch. azido-<wbr></wbr>FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.
| Catalog Number | R024444 |
| CAS Number | 881914-35-8 |
| Synonyms | 2-amino-2-[2-(4-(1-azido-2-octylphenyl))ethyl]-1,3-propanediol |
| Molecular Formula | C19H32N4O2 |
| Purity | ≥95% |
| Target | Azide |
| Storage | -20°C |
| InChI | InChI=1S/C19H32N4O2/c1-2-3-4-5-6-7-8-17-10-9-16(13-18(17)22-23-21)11-12-19(20,14-24)15-25/h9-10,13,24-25H,2-8,11-12,14-15,20H2,1H3 |
| InChIKey | FLPFGLNTCQQHNS-UHFFFAOYSA-N |
| SMILES | CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1CN=[N]=N |
| Reference | 1.Brinkmann, V.,Pinschewer, D.D.,Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72, 764-769 (2001). |
