Azido-PEG1-azide

• CAT Number: R008656
• CAS Number: 24345-74-2
• Molecular Formula: C4H8N6O
• Molecular Weight: 156.15
• Purity: ≥95%
• Synonyms: 1-azido-2-(2-azidoethoxy)ethane
• InChI: InChI=1S/C4H8N6O/c5-9-7-1-3-11-4-2-8-10-6/h1-4H2
• InChIKey: NQEPBRYUGPSVPU-UHFFFAOYSA-N
• SMILES: C(COCCN=[N+]=[N-])N=[N+]=[N-]

Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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