Azido-PEG1-Boc

• CAT Number: I015820
• CAS Number: 1374658-85-1
• Molecular Formula: C9H17N3O3
• Molecular Weight: 215.25
• Purity: ≥95%
• Synonyms: tert-butyl 3-(2-azidoethoxy)propanoate
• InChI: InChI=1S/C9H17N3O3/c1-9(2,3)15-8(13)4-6-14-7-5-11-12-10/h4-7H2,1-3H3
• InChIKey: YQLWGRGAPJGNNQ-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCN=[N+]=[N-]

Azido-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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