Azido-PEG1-CH2CO2H

• CAT Number: I017489
• CAS Number: 79598-48-4
• Molecular Formula: C4H7N3O3
• Molecular Weight: 145.12
• Purity: ≥95%
• Synonyms: 2-(2-azidoethoxy)acetic acid
• InChI: InChI=1S/C4H7N3O3/c5-7-6-1-2-10-3-4(8)9/h1-3H2,(H,8,9)
• InChIKey: USTXYASKHZDVMV-UHFFFAOYSA-N
• SMILES: C(COCC(=O)O)N=[N+]=[N-]

Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1[1]. Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Reference

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.Bioorg Med Chem. 2020 Jan 1;28(1):115228.
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