Azido-PEG2-CH2COOH

• CAT Number: I017253
• CAS Number: 882518-90-3
• Molecular Formula: C6H11N3O4
• Molecular Weight: 189.17
• Purity: ≥95%
• Synonyms: 2-[2-(2-azidoethoxy)ethoxy]acetic acid
• InChI: InChI=1S/C6H11N3O4/c7-9-8-1-2-12-3-4-13-5-6(10)11/h1-5H2,(H,10,11)
• InChIKey: OCIIYNXOTJRSHW-UHFFFAOYSA-N
• SMILES: C(COCCOCC(=O)O)N=[N+]=[N-]

Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. Yimin Qian, et al. Composés et procédés pour la dégradation ciblée de protéines contenant un bromodomaine. WO2017030814A1.