For research use only. Not for therapeutic Use.
Azido-PEG3-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-aldehyde is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044622 |
| CAS Number | 1807530-10-4 |
| Synonyms | 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanal |
| Molecular Formula | C9H17N3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H17N3O4/c10-12-11-2-5-15-7-9-16-8-6-14-4-1-3-13/h3H,1-2,4-9H2 |
| InChIKey | NYVGWHGMRDHPFF-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCN=[N+]=[N-])C=O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
