Azido-PEG3-SS-NHS

For research use only. Not for therapeutic Use.

  • CAT Number: I045947
  • Molecular Formula: C15H24N4O7S2
  • Molecular Weight: 436.50
  • Purity: ≥95%
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Azido-PEG3-SS-NHS is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-SS-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].


Catalog Number I045947
Synonyms

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyldisulfanyl]propanoate

Molecular Formula C15H24N4O7S2
Purity ≥95%
InChI InChI=1S/C15H24N4O7S2/c16-18-17-4-5-23-6-7-24-8-9-25-10-12-28-27-11-3-15(22)26-19-13(20)1-2-14(19)21/h1-12H2
InChIKey GULGJNLQJQCHEW-UHFFFAOYSA-N
SMILES C1CC(=O)N(C1=O)OC(=O)CCSSCCOCCOCCOCCN=[N+]=[N-]
Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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