Azido-PEG4-CH2-Boc

• CAT Number: I017198
• CAS Number: 864681-04-9
• Molecular Formula: C₁₄H₂₇N₃O₆
• Molecular Weight: 333.38
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: tert-butyl 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]acetate
• InChI: InChI=1S/C14H27N3O6/c1-14(2,3)23-13(18)12-22-11-10-21-9-8-20-7-6-19-5-4-16-17-15/h4-12H2,1-3H3
• InChIKey: SIOLYQZSIFQODW-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)COCCOCCOCCOCCN=[N+]=[N-]

Azido-PEG4-CH2-Boc (Cat.No:I017198) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 

Reference

[1]. Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1.[2]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.