For research use only. Not for therapeutic Use.
Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
| Catalog Number | I016808 |
| CAS Number | 2055024-64-9 |
| Synonyms | (2S)-2-[N-[(2S)-2-[3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]-4-(hydroxymethyl)anilino]-5-(carbamoylamino)pentanamide |
| Molecular Formula | C29H48N8O9 |
| Purity | ≥95% |
| InChI | InChI=1S/C29H48N8O9/c1-21(2)26(35-25(39)9-12-43-14-16-45-18-19-46-17-15-44-13-11-34-36-32)28(41)37(23-7-5-22(20-38)6-8-23)24(27(30)40)4-3-10-33-29(31)42/h5-8,21,24,26,38H,3-4,9-20H2,1-2H3,(H2,30,40)(H,35,39)(H3,31,33,42)/t24-,26-/m0/s1 |
| InChIKey | YKWCEPIPEDFAAV-AHWVRZQESA-N |
| SMILES | CC(C)C(C(=O)N(C1=CC=C(C=C1)CO)C(CCCNC(=O)N)C(=O)N)NC(=O)CCOCCOCCOCCOCCN=[N+]=[N-] |
| Reference | [1]. Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
