Azido-PEG5-CH2CO2H

• CAT Number: I017032
• CAS Number: 217180-81-9
• Molecular Formula: C₁₂H₂₃N₃O₇
• Molecular Weight: 321.33
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: 2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C12H23N3O7/c13-15-14-1-2-18-3-4-19-5-6-20-7-8-21-9-10-22-11-12(16)17/h1-11H2,(H,16,17)
• InChIKey: CEACGPKHPWXRQF-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCC(=O)O)N=[N+]=[N-]

Azido-PEG5-CH2CO2H (Cat.No:I017032) is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Reference

[1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.