Azido-PEG8-acid

• CAT Number: I016800
• CAS Number: 1214319-92-2
• Molecular Formula: C₁₉H₃₇N₃O₁₀
• Molecular Weight: 467.51
• Purity: ≥95%
• Target: PROTAC
• Storage: -20°C
• IUPAC Name: 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C19H37N3O10/c20-22-21-2-4-26-6-8-28-10-12-30-14-16-32-18-17-31-15-13-29-11-9-27-7-5-25-3-1-19(23)24/h1-18H2,(H,23,24)
• InChIKey: URUGOEBULOZLBF-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O

Azido-PEG8-acid（Cat No.:I016800） is a non-cleavable linker composed of an eight-unit polyethylene glycol (PEG) chain with an azido functional group at one end and a carboxylic acid at the other end. It is primarily used in the synthesis of antibody-drug conjugates (ADCs), where it serves as a bridge between the antibody and the cytotoxic drug payload. Additionally, Azido-PEG8-acid can be utilized as a PEG-based linker in the construction of PROTACs (proteolysis-targeting chimeras), a class of molecules designed for targeted protein degradation.

Reference

[1]. Tan M, et al. Peptide-targeted Nanoglobular Gd-DOTA monoamide conjugates for magnetic resonance cancer molecular imaging. Biomacromolecules. 2010 Mar 8;11(3):754-61.