Azidoprazosin

• CAT Number: I022921
• CAS Number: 90990-97-9
• Molecular Formula: C21H21IN8O3
• Molecular Weight: 560.36
• Purity: 98%
• Synonyms: (125I)Iodoarylazidoprazosin; 125I-Iaap; Aryl azidoprazosin; Azidoprazosin; CP 65,526; Iodoaryl azidoprazosin
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(4-azido-3-iodophenyl)methanone
• InChI: InChI=1S/C21H21IN8O3/c1-32-17-10-13-16(11-18(17)33-2)25-21(26-19(13)23)30-7-5-29(6-8-30)20(31)12-3-4-15(27-28-24)14(22)9-12/h3-4,9-11H,5-8H2,1-2H3,(H2,23,25,26)
• InChIKey: HCZCARLOZFORBR-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC(=C(C=C4)N=[N+]=[N-])I)N)OC

Azidoprazosin(CAT: I022921) is a photoaffinity ligand derived from prazosin, a selective α1-adrenergic receptor antagonist. It incorporates an azido group, enabling covalent binding to target proteins upon UV activation. This property makes azidoprazosin an invaluable tool in biochemical and pharmacological research for studying α1-adrenergic receptors, mapping receptor binding sites, and elucidating protein interactions. Its specificity and photoactivation capability allow researchers to investigate adrenergic signaling pathways and the structural biology of receptor-ligand interactions. Azidoprazosin is particularly useful in receptor characterization, drug discovery, and understanding adrenergic system regulation in cardiovascular and neurological systems.