For research use only. Not for therapeutic Use.
Azimilide Dihydrochloride (CAT: I001851), also known as NE-10064 Dihydrochloride, is a class III antiarrhythmic compound. It exerts its effects by inhibiting the potassium ion channels I(Ks) and I(Kr) in guinea-pig cardiac myocytes, as well as the I(Ks) (minK) channels expressed in Xenopus oocytes. By blocking these potassium channels, Azimilide Dihydrochloride helps to regulate the electrical activity of the heart, which can be beneficial in the treatment of certain cardiac arrhythmias.
| Catalog Number | I001851 |
| CAS Number | 149888-94-8 |
| Synonyms | 1-[(E)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino]-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione;dihydrochloride |
| Molecular Formula | C23H30Cl3N5O3 |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | DMSO: ＜ 10.4 mg/mL |
| Storage | Store at -20°C |
| Reference | <p style=/line-height:25px/> <br>[1]. Busch AE, et al. Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action. Br J Pharmacol. 1998 Jan;123(1):23-30. <br>[2]. Yao JA, et al. Azimilide (NE-10064) can prolong or shorten the action potential duration in canine ventricular myocytes: dependence on blockade of K, Ca, and Na channels. J Cardiovasc Electrophysiol. 1997 Feb;8(2):184-98. <br>[3]. Fermini B, et al. Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: block of delayed rectifier potassium and L-type calcium currents. J Cardiovasc Pharmacol. 1995 Aug;26(2):259-71. <br>[4]. Black SC, et al. Protection against programmed electrical stimulation-induced ventricular tachycardia and sudden cardiac death by NE-10064, a class III antiarrhythmic drug. J Cardiovasc Pharmacol. 1993 Dec;22(6):810-8. |
