AZT triphosphate

• CAT Number: I015369
• CAS Number: 92586-35-1
• Molecular Formula: C₁₀H₁₆N₅O₁₃P₃
• Molecular Weight: 507.18
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• IUPAC Name: [[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• InChI: InChI=1S/C10H16N5O13P3/c1-5-3-15(10(17)12-9(5)16)8-2-6(13-14-11)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h3,6-8H,2,4H2,1H3,(H,21,22)(H,23,24)(H,12,16,17)(H2,18,19,20)/t6-,7+,8+/m0/s1
• InChIKey: GLWHPRRGGYLLRV-XLPZGREQSA-N
• SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N=[N+]=[N-]

AZT Triphosphate（Cat No.:I015369）is the active metabolite of Zidovudine (AZT), a nucleoside reverse transcriptase inhibitor (NRTI) used in HIV treatment. It inhibits HIV replication by competing with natural nucleotides for incorporation into viral DNA, leading to chain termination during reverse transcription. AZT Triphosphate’s mechanism of action makes it a critical tool for understanding viral replication and resistance mechanisms. It is extensively studied in antiviral research, contributing to the development of optimized dosing regimens and combination therapies to improve the efficacy and safety of antiretroviral treatments.