For research use only. Not for therapeutic Use.
Dopamine D2 receptor agonist, α2-adrenoceptor partial agonist
| Catalog Number | I047533 |
| CAS Number | 36085-44-6 |
| Molecular Formula | C14H16ClN3S.2HCl |
| Purity | ≥95% |
| IUPAC Name | 6-[(4-chlorophenyl)methyl]-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine;dihydrochloride |
| InChI | InChI=1S/C14H16ClN3S.2ClH/c15-11-3-1-10(2-4-11)9-18-7-5-12-13(6-8-18)19-14(16)17-12;;/h1-4H,5-9H2,(H2,16,17);2*1H |
| SMILES | C1CN(CCC2=C1N=C(S2)N)CC3=CC=C(C=C3)Cl.Cl.Cl |
| Reference | MJ Brown and D Harland. B-HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors. Br. J. Pharmacol. 1986, 87(2), 361–370.
G Cichini et al. B-HT 920 and B-HT 958: Presynaptic effects on electrically evoked 3H-dopamine release from slices of rat nucleus accumbens. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1987, 335, 28-31.
L Pichler et al. B-HT 958, a new α-adrenoceptor agonist with a high pre/postsynaptic activity ratio. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1982, 320, 2, 110-114.
Hörtnagl H et al. B-HT 958–an antagonist at alpha 2-adrenoceptors and an agonist at dopamine autoreceptors in the brain. Eur. J. Pharmacol. 1984, 106(2), 335-344. |
