B-Raf IN 1

• CAT Number: I005645
• CAS Number: 950736-05-7
• Molecular Formula: C29H24F3N5O
• Molecular Weight: 515.53
• Purity: ≥95%
• Synonyms: (Z)-N-(3-(3-(4-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzimidic acid
• Target: Raf
• Solubility: DMSO: ≥ 53 mg/mL
• Storage: Store at -20°C
• IC50: 24 nM (B-Raf); 25 nM (C-Raf)
• IUPAC Name: N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide
• InChI: InChI=1S/C29H24F3N5O/c1-36(2)18-19-9-11-20(12-10-19)25-17-34-37-26(13-14-33-27(25)37)21-5-4-8-24(16-21)35-28(38)22-6-3-7-23(15-22)29(30,31)32/h3-17H,18H2,1-2H3,(H,35,38)
• InChIKey: AIWJVLQNYNCDSL-UHFFFAOYSA-N
• SMILES: O=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5

B-Raf IN 1(CAT: I005645) is a highly potent and selective inhibitor of B-Raf kinase, with an IC50 of 24 nM. It is equally effective against c-Raf, with an IC50 of 25 nM, making it a dual Raf kinase inhibitor. By targeting the MAPK/ERK signaling pathway, B-Raf IN 1 disrupts cellular proliferation and survival signals, particularly in cancer cells with aberrant Raf activity. This compound is highly relevant in oncology research, where it is used to study Raf-mediated signaling and to develop targeted therapies for cancers driven by B-Raf mutations or overactive MAPK pathways. Its potency and dual specificity provide a robust tool for exploring Raf kinases as therapeutic targets.