B-Raf IN 15

• CAT Number: I040926
• CAS Number: 832107-31-0
• Molecular Formula: C19H15N3OS
• Molecular Weight: 333.41
• Purity: ≥95%
• Synonyms: 7-[(pyridin-3-ylamino)-thiophen-3-ylmethyl]quinolin-8-ol
• InChI: InChI=1S/C19H15N3OS/c23-19-16(6-5-13-3-1-9-21-18(13)19)17(14-7-10-24-12-14)22-15-4-2-8-20-11-15/h1-12,17,22-23H
• InChIKey: KSWFNFIKRRTNCX-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C(C=C2)C(C3=CSC=C3)NC4=CN=CC=C4)O)N=C1

B-Raf IN 15 (Compound 7) is a BRAF inhibitor. B-Raf IN 15 inhibits BRAF WT and BRAF V600E with IC50s of 2.0 and 0.8 μM. B-Raf IN 15 can be used for the research of cancer[1].

Reference

[1]. Qin J, et al. Identification of a novel family of BRAF(V600E) inhibitors. J Med Chem. 2012 Jun 14;55(11):5220-30.
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