For research use only. Not for therapeutic Use.
B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer[1].
B-Raf IN 2 shows considerably less paradoxial activation of the MAPK signaling pathway while retaining high potency[1].
| Catalog Number | I045175 |
| CAS Number | 2649372-20-1 |
| Synonyms | (3R)-N-[2-cyano-4-fluoro-3-(3-methyl-4-oxoquinazolin-6-yl)oxyphenyl]-3-fluoropyrrolidine-1-sulfonamide |
| Molecular Formula | C20H17F2N5O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H17F2N5O4S/c1-26-11-24-17-4-2-13(8-14(17)20(26)28)31-19-15(9-23)18(5-3-16(19)22)25-32(29,30)27-7-6-12(21)10-27/h2-5,8,11-12,25H,6-7,10H2,1H3/t12-/m1/s1 |
| InChIKey | ZUXPFTYMSHPRQX-GFCCVEGCSA-N |
| SMILES | CN1C=NC2=C(C1=O)C=C(C=C2)OC3=C(C=CC(=C3C#N)NS(=O)(=O)N4CCC(C4)F)F |
| Reference | [1]. Dolente C, et, al. New methylquinazolinone derivatives. WO2021116055A1. |
