B-Raf inhibitor 1 (Compound 13) dihydrochloride

• CAT Number: I000693
• CAS Number: 1191385-19-9
• Molecular Formula: C26H21Cl3N8
• Molecular Weight: 551.86
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6.Cl.Cl

B-Raf inhibitor 1 (Compound 13) is a type IIA Raf inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively.

Reference

[1] Wang X,J Med Chem. 2012 13;55(17):7332-41. Kim J.