B-Raf Inhibitor 1

• CAT Number: I000391
• CAS Number: 1093100-40-3
• Molecular Formula: C₂₆H₁₉ClN₈
• Molecular Weight: 478.94
• Purity: ≥95%
• Synonyms: 1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine
• Target: Raf
• Solubility: DMSO: ≥ 53 mg/mL
• Storage: Store at -20C
• IC50: 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK [1]
• InChI: InChI=1S/C26H19ClN8/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33)
• InChIKey: KKVYYGGCHJGEFJ-UHFFFAOYSA-N
• SMILES: CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6

B-Raf Inhibitor 1 (CAT: I000391) is a robust and specific inhibitor targeting B-Raf, a critical component of the MAPK signaling pathway. With notable potency, it displays cell IC50 values of 0.31 µM for A375 cell proliferation and 2 nM for inhibiting A375 p-ERK levels. By disrupting B-Raf activity, this inhibitor hinders downstream ERK phosphorylation, impeding oncogenic signaling and potentially interfering with cancer cell growth.

Reference

[1]. Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41.