B-SITOSTENONE

• CAT Number: M067828
• CAS Number: 1058-61-3
• Molecular Formula: C29H48O
• Molecular Weight: 412.69
• Purity: ≥95%
• Synonyms: Stigmast-4-en-3-one; beta-sitostenone
• Storage: -20°C
• IUPAC Name: (8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h18-21,24-27H,7-17H2,1-6H3/t20-,21-,24+,25-,26+,27+,28+,29-/m1/s1
• InChIKey: RUVUHIUYGJBLGI-XJZKHKOHSA-N
• SMILES: CCC(CCC(C)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(C)C

β-Sitostenone (Cat.No:M067828) is a phytosterol compound commonly found in plants. It is structurally similar to cholesterol and belongs to the group of plant sterols. β-Sitostenone is believed to have potential health benefits, including its role in reducing cholesterol absorption in the intestines, making it of interest in the field of nutrition and health.

Reference

1. Molecules. 2015 Jul 3;20(7):12166-74. doi: 10.3390/molecules200712166.Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties.Chu CW(1), Liu CM(2), Chung MI(3), Chen CY(4).

 

Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (-)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (-)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (-)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (-)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening.