B591

• CAT Number: I047642
• CAS Number: 1498412-41-1
• Molecular Formula: C25H24Br2N2O
• Molecular Weight: 528.28
• Purity: ≥95%
• IUPAC Name: 1-[(2-bromophenyl)methyl]-3-(2,3-dihydro-1-benzofuran-5-ylmethyl)-5,6-dimethylbenzimidazol-3-ium;bromide
• InChI: InChI=1S/C25H24BrN2O.BrH/c1-17-11-23-24(12-18(17)2)28(15-21-5-3-4-6-22(21)26)16-27(23)14-19-7-8-25-20(13-19)9-10-29-25;/h3-8,11-13,16H,9-10,14-15H2,1-2H3;1H/q+1;/p-1
• SMILES: CC1=CC2=C(C=C1C)[N+](=CN2CC3=CC=CC=C3Br)CC4=CC5=C(C=C4)OCC5.[Br-]

B591 is a specific pan-PI3K inhibitor with potent inhibitory activity against class I PI3K isoforms (IC50 values of 1.300, 0.364, 0.107 and 1.580 μM for PI3Kα, PI3Kβ, PI3Kβγ, PI3Kδ, respectively), which showed effective inhibition of cellular PI3K/mTOR signaling pathway and robust antitumor activity in a set of cancer cell lines. Cancer stem cells (CSCs) targeting agent.
KEYWORDS: B591 | supplier | PI3K inhibitor | PI3K inhibitor B591 | B 591 | B-591 | PI3K inhibitor B 591 | PI3K inhibitor B-591 | CAS [1498412-41-1] | [1499285-30-1] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes | CSC | Cancer stem cell

Reference

H Zhou et al. B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells. Oncogene. 2019 May;38(18):3371-3386.