For research use only. Not for therapeutic Use.
Baclofen (Cat.No:I000504) is a medication used to treat muscle spasms and spasticity. It is a GABA receptor agonist that works by inhibiting the release of excitatory neurotransmitters. Baclofen is commonly prescribed to patients with multiple sclerosis, cerebral palsy, and spinal cord injuries. It is available in oral and injectable forms and can cause side effects such as dizziness, drowsiness, and weakness.
Catalog Number | I000504 |
CAS Number | 1134-47-0 |
Synonyms | β-(aminomethyl)-4-chloro-benzenepropanoic acid |
Molecular Formula | C10H12ClNO2 |
Purity | ≥95% |
Target | Neuronal Signaling |
Solubility | DMSO < 7.8 mg/mL |
Storage | Store at -20°C |
IUPAC Name | 4-amino-3-(4-chlorophenyl)butanoic acid |
InChI | InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) |
InChIKey | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
SMILES | C1=CC(=CC=C1C(CC(=O)O)CN)Cl |
Reference | </br>1:A Randomized, Placebo-Controlled Study of High-Dose Baclofen in Alcohol-Dependent Patients-The ALPADIR Study. Reynaud M, Aubin HJ, Trinquet F, Zakine B, Dano C, Dematteis M, Trojak B, Paille F, Detilleux M.Alcohol Alcohol. 2017 May 19:1-8. doi: 10.1093/alcalc/agx030. [Epub ahead of print] PMID: 28525555 </br>2:The dose-effect relationship of baclofen in alcohol dependence: A 1-year cohort study. Pignon B, Labreuche J, Auffret M, Gautier S, Deheul S, Simioni N, Cottencin O, Bordet R, Duhamel A, Rolland B.Hum Psychopharmacol. 2017 May 18. doi: 10.1002/hup.2593. [Epub ahead of print] PMID: 28517239 </br>3:Recurrent Episodes of Brief Global Amnesia Related to Intrathecal Baclofen Pump: Originally Mistaken for Psychogenic Nonepileptic Seizures. Rosenblum D, Noorani G, Desan PH.Psychosomatics. 2017 Mar 16. pii: S0033-3182(17)30077-4. doi: 10.1016/j.psym.2017.03.011. [Epub ahead of print] No abstract available. PMID: 28501288 </br>4:Percutaneous Endoscopic Gastrostomy in a Patient With Continuous Intrathecal Baclofen Infusion Therapy. Toh Yoon EW, Kobayashi M.Gastroenterology Res. 2017 Apr;10(2):132-134. doi: 10.14740/gr786w. Epub 2017 Apr 19. PMID: 28496536 Free PMC Article</br>5:Speaking fluently with baclofen? Beraha E, Bodewits P, van den Brink W, Wiers R.BMJ Case Rep. 2017 May 11;2017. pii: bcr-2016-218714. doi: 10.1136/bcr-2016-218714. PMID: 28495786 </br>6:Persistent Hiccups after an Epidural Steroid Injection Successfully Treated with Baclofen: A Case Report. Colorado B, Decker G.PM R. 2017 May 5. pii: S1934-1482(16)31266-7. doi: 10.1016/j.pmrj.2017.04.013. [Epub ahead of print] PMID: 28483686 </br>7:Management of intrathecal baclofen therapy for severe acquired brain injury: consensus and recommendations for good clinical practice. De Tanti A, Scarponi F, Bertoni M, Gasperini G, Lanzillo B, Molteni F, Posteraro F, Vitale DF, Zanpolini M; ITB Italian Group..Neurol Sci. 2017 May 6. doi: 10.1007/s10072-017-2972-z. [Epub ahead of print] PMID: 28478498 </br>8:Intrathecal baclofen pump infection treated by adjunct intrareservoir teicoplanin instillation. Aristedis R, Dimitrios P, Nikolaos P, Alexandros B.Surg Neurol Int. 2017 Mar 14;8:38. doi: 10.4103/sni.sni_418_16. eCollection 2017. PMID: 28458952 Free PMC Article</br>9:GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the <i>Fmr1</i> Knockout Mouse Model of Fragile X Syndrome. Sinclair D, Featherstone R, Naschek M, Nam J, Du A, Wright S, Pance K, Melnychenko O, Weger R, Akuzawa S, Matsumoto M, Siegel SJ.eNeuro. 2017 Mar 1;4(1). pii: ENEURO.0380-16.2017. doi: 10.1523/ENEURO.0380-16.2017. eCollection 2017 Jan-Feb. PMID: 28451631 Free PMC Article</br>10:Baclofen Abuse due to Its Hypomanic Effect in Patients with Alcohol Dependence and Comorbid Major Depressive Disorder. Ghosh S, Bhuyan D.Clin Psychopharmacol Neurosci. 2017 May 31;15(2):187-189. doi: 10.9758/cpn.2017.15.2.187. PMID: 28449569 Free PMC Article |