For research use only. Not for therapeutic Use.
Bacoside A<sub>3</sub> is a triterpenoid saponin first isolated from <em>B. monniera</em>. Bacoside A<sub>3</sub> inhibits the ATP-binding cassette transporter P-glycoprotein (P-gp), decreasing efflux 4-fold compared with control <em>in vitro</em>. An extract containing bacoside A<sub>3</sub> and bacopaside II (4 and 1.3 µg/mg extract, respectively) administered for eight days at a dose of 10-30 mg/kg reduces opioid withdrawal-induced depression in mice using the forced swim test. Bacoside A<sub>3</sub> also has antioxidant properties following liver and kidney damage induced by street heroin in rats.
| Catalog Number | R023136 |
| CAS Number | 157408-08-7 |
| Synonyms | (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-α-L-arabinofuranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranoside, |
| Molecular Formula | C47H76O18 |
| Purity | ≥95% |
| Target | Plants |
| Storage | -20°C |
| InChI | InChI=1S/C47H76O18/c1-21(2)14-22-15-45(7,57)38-23-8-9-28-43(5)12-11-29(42(3,4)27(43)10-13-44(28,6)46(23)19-47(38,65-22)58-20-46)62-41-37(64-39-34(55)31(52)25(17-49)60-39)36(32(53)26(18-50)61-41)63-40-35(56)33(54)30(51)24(16-48)59-40/h14,22-41,48-57H,8-13,15-20H2,1-7H3/t22-,23+,24+,25-,26+,27-,28+,29-,30+,31-,32+,33-,34+,35+,36-,37+,38-,39-,40-,41-,43-,44+,45-,46-,47-/m0/s1 |
| InChIKey | CDEVGTJBRPBOPH-INTDMYAHSA-N |
| SMILES | CC(=CC1CC(C2C3CCC4C5(CCC(C(C5CCC4(C36CC2(O1)OC6)C)(C)C)OC7C(C(C(C(O7)CO)O)OC8C(C(C(C(O8)CO)O)O)O)OC9C(C(C(O9)CO)O)O)C)(C)O)C |
