For research use only. Not for therapeutic Use.
Bactenecin（Cat No.:M134807）is a potent antimicrobial peptide (AMP) primarily found in bovine neutrophils. Known for its broad-spectrum activity, it effectively targets a range of Gram-positive and Gram-negative bacteria by disrupting their cell membranes, leading to cell lysis. Bactenecin is part of the innate immune response, offering rapid action against bacterial infections. Due to its unique properties, it’s a subject of interest in research for developing novel antibiotic agents, especially in combating drug-resistant bacteria. Its role in immunity makes it a valuable tool in infectious disease studies.
| CAS Number | 116229-36-8 |
| Molecular Formula | C63H118N24O13S2 |
| Purity | ≥95% |
| Target | Bacterial |
| Storage | -20°C |
| IUPAC Name | 2-[[28-[[2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-13,22-di(butan-2-yl)-10,25-bis[3-(diaminomethylideneamino)propyl]-6,9,12,15,18,21,24,27-octaoxo-7,16,19-tri(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26-octazacyclononacosane-4-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| InChI | InChI=1S/C63H118N24O13S2/c1-13-34(11)46-57(97)78-38(21-17-25-75-62(69)70)49(89)83-43(31(5)6)54(94)82-42(53(93)79-39(59(99)100)22-18-26-76-63(71)72)29-102-101-28-41(81-51(91)40(27-30(3)4)80-48(88)36(64)19-15-23-73-60(65)66)52(92)77-37(20-16-24-74-61(67)68)50(90)86-47(35(12)14-2)58(98)85-44(32(7)8)55(95)84-45(33(9)10)56(96)87-46/h30-47H,13-29,64H2,1-12H3,(H,77,92)(H,78,97)(H,79,93)(H,80,88)(H,81,91)(H,82,94)(H,83,89)(H,84,95)(H,85,98)(H,86,90)(H,87,96)(H,99,100)(H4,65,66,73)(H4,67,68,74)(H4,69,70,75)(H4,71,72,76) |
| InChIKey | RHISNKCGUDDGEG-UHFFFAOYSA-N |
| SMILES | CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)N)C(=O)NC(CCCN=C(N)N)C(=O)O)C(C)C)CCCN=C(N)N)C(C)CC)C(C)C)C(C)C |
| Reference | Gagnon, Matthieu G., Raktim N. Roy, Ivan B. Lomakin, Tanja Florin, Alexander S. Mankin, and Thomas A. Steitz. /Structures of Proline-rich Peptides Bound to the Ribosome Reveal a Common Mechanism of Protein Synthesis Inhibition./ Nucleic Acids Res Nucleic Acids Research (2016)</span></p> |
