For research use only. Not for therapeutic Use.
Bafilomycin B1(Cat No.:R003438)is a potent inhibitor of vacuolar-type H+-ATPases (V-ATPases), which play a critical role in regulating intracellular pH, ion homeostasis, and vesicular trafficking. This antibiotic compound is widely used in cell biology and pharmaceutical research to study cellular processes such as autophagy, endocytosis, and intracellular acidification. Bafilomycin B1 is particularly valuable in cancer research, where it can be used to modulate the acidic tumor microenvironment. Its selective inhibition of V-ATPases also has implications in drug delivery and potential therapeutic strategies for diseases involving abnormal vesicular function.
Catalog Number | R003438 |
CAS Number | 88899-56-3 |
Synonyms | Setamycin |
Molecular Formula | C44H65NO13 |
Purity | 95% |
Target | Bacterial |
Appearance | Off-white to pale yellow solid |
Storage | -20°C |
Overview of Clinical Research | <input border=”0″ class=”np” height=”22″ name=”imageField” src=”/uploads/allimg/190820/162910B08-0.gif” style=”cursor:pointer” type=”image” width=”60″ /> |
Analysis method | HPLC |
IUPAC Name | [2-hydroxy-2-[3-hydroxy-4-(10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl)pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl] 4-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-4-oxobut-2-enoate |
InChI | InChI=1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48) |
InChIKey | KFUFLYSBMNNJTF-UHFFFAOYSA-N |
SMILES | CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)NC3=C(CCC3=O)O)O)O)OC)C |
Reference | Bafilolides, Potent Inhibitors of the Motility and Development of the Free-Living Stages of Parasitic Nematodes. Lacey E. et al. Int. J. Parasitol. 1995, 25, 349. <br /> |