Bafilomycin B1

For research use only. Not for therapeutic Use.

  • CAT Number: R003438
  • CAS Number: 88899-56-3
  • PubChem Substance ID: 6440917
  • Molecular Formula: C44H65NO13
  • Molecular Weight: 816.00
  • Purity: 95%
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Bafilomycin B1(Cat No.:R003438)is a potent inhibitor of vacuolar-type H+-ATPases (V-ATPases), which play a critical role in regulating intracellular pH, ion homeostasis, and vesicular trafficking. This antibiotic compound is widely used in cell biology and pharmaceutical research to study cellular processes such as autophagy, endocytosis, and intracellular acidification. Bafilomycin B1 is particularly valuable in cancer research, where it can be used to modulate the acidic tumor microenvironment. Its selective inhibition of V-ATPases also has implications in drug delivery and potential therapeutic strategies for diseases involving abnormal vesicular function.


Catalog Number R003438
CAS Number 88899-56-3
Synonyms

Setamycin

Molecular Formula C44H65NO13
Purity 95%
Target Bacterial
Appearance Off-white to pale yellow solid
Storage -20°C
Overview of Clinical Research

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Analysis method HPLC
IUPAC Name [2-hydroxy-2-[3-hydroxy-4-(10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl)pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl] 4-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-4-oxobut-2-enoate
InChI InChI=1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)
InChIKey KFUFLYSBMNNJTF-UHFFFAOYSA-N
SMILES CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)NC3=C(CCC3=O)O)O)O)OC)C
Reference

Bafilolides, Potent Inhibitors of the Motility and Development of the Free-Living Stages of Parasitic Nematodes. Lacey E. et al. Int. J. Parasitol. 1995, 25, 349.&nbsp;<br />
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Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis. Xu J. et al. Histol. Histopathol. 2007, 22, 443.
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