For research use only. Not for therapeutic Use.
Bafilomycin C1（Cat No.:R003305）is a potent, selective inhibitor of vacuolar-type H+-ATPase (V-ATPase), which plays a critical role in acidifying intracellular compartments. By inhibiting V-ATPase, Bafilomycin C1 disrupts processes such as protein degradation, membrane trafficking, and autophagy. It is widely used in research to study lysosomal function, endocytosis, and the role of acidic environments in cellular processes. Additionally, it is valuable in investigations of drug resistance mechanisms in cancer and other diseases, as well as potential therapies targeting cellular pH regulation.
| Catalog Number | R003305 |
| CAS Number | 88979-61-7 |
| Synonyms | 2E-butenedioic acid-1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylet |
| Molecular Formula | C39H60O12 |
| Purity | 95% |
| Target | Membrane Transporter/Ion Channel |
| Solubility | Soluble in DMSO |
| Appearance | White Powder |
| Storage | -20°C |
| Analysis method | HPLC |
| IUPAC Name | (E)-4-[(2R,4R,5S,6R)-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl]oxy-4-oxobut-2-enoic acid |
| InChI | InChI=1S/C39H60O12/c1-21(2)36-26(7)31(49-33(42)16-15-32(40)41)20-39(46,51-36)28(9)35(44)27(8)37-29(47-10)14-12-13-22(3)17-24(5)34(43)25(6)18-23(4)19-30(48-11)38(45)50-37/h12-16,18-19,21,24-29,31,34-37,43-44,46H,17,20H2,1-11H3,(H,40,41)/b14-12-,16-15+,22-13+,23-18+,30-19-/t24-,25+,26-,27-,28-,29-,31+,34-,35+,36+,37?,39+/m0/s1 |
| InChIKey | WUDBXVQNMOTFEE-IUJNTKNESA-N |
| SMILES | C[C@H]1C/C(=C/C=C\[C@@H](C(OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)OC(=O)/C=C/C(=O)O)O)O)OC)/C |
| Reference | Bafilolides, Potent Inhibitors of the Motility and Development of the Free-Living Stages of Parasitic Nematodes. Lacey E. et al. Int. J. Parasitol. 1995, 25, 349. <br /> |
