For research use only. Not for therapeutic Use.
BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. BAL-0028 also exhibits anti-inflammatory activity.
| Catalog Number | I047178 |
| CAS Number | 2842012-69-3 |
| Molecular Formula | C24H22FN3O2 |
| Purity | ≥95% |
| Reference | [1] Hartman G, et al. Bioorg Med Chem Lett. 2024 Apr 1:102:129675. |
